Medicine

Novel Compound Strongly Inhibits Botulinum Neurotoxin

A newly-identified natural compound called nitrophenyl psoralen could be used as a treatment to reduce paralysis induced by botulism, a rare illness caused by toxins that attack the nervous system. Mechanism of action of botulinum toxin: the light chain of (BT-A) cleaves SNAP-25 (synaptosome-associated protein of 25 KDa) and consequently …

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Novel Probiotic-Antibiotic Combination Eradicates Drug-Resistant Bacteria

A team of researchers from Massachusetts Institute of Technology has developed a novel approach for eradicating methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa from wounds, using a combination of antibiotics and alginate-encapsulated probiotics. The team’s work appears in the journal Advanced Materials. Li et al devised a way to encapsulate …

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Novel Therapeutic Delivers Oxygen to Hypoxic Tissues

Researchers from the University of California at San Francisco (UCSF) have developed a novel therapeutic that can deliver oxygen specifically to under-oxygenated tissues, thereby restoring the contractile function of cardiac cells, which is heavily affected under hypoxic conditions. The study is published in the journal PLoS Biology. A new oxygen-delivery …

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Linalool Odor is Relaxing, New Study Confirms

A study carried out by Kagoshima University researchers shows that linalool, a constituent of lavender, peppermint and many other essential oils, must be smelt — not absorbed in the lungs — to exert its calming effects, which could be used to relieve preoperative stress and anxiety disorders. Harada et al …

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Caffeinated Coffee Consumption Lowers Risk of Rosacea: Study

Consuming caffeine from coffee but not from other foods is associated with a lower risk of rosacea, a common chronic inflammatory skin disease, according to a new study published in the journal JAMA Dermatology. Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Image credit: …

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Engineered Enzyme Could Treat Nicotine Addiction

A team of scientists at the Scripps Research Institute has synthesized a new nicotine-degrading enzyme and successfully tested it in nicotine-dependent rats. Named NicA2-J1, the engineered enzyme decreased blood nicotine levels and had remarkable efficacy in reducing addiction-like behaviors in the rodents. The results appear in the journal Science Advances. …

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Green Tea Polyphenol Helps Therapeutic RNAs Slip Inside Cells

Epigallocatechin gallate (EGCG) is the major polyphenol in the leaves of green tea (Camellia sinensis). This compound is the subject of increasing research interest because it has demonstrated beneficial effects in studies of diabetes, Parkinson’s and Alzheimer’s diseases, stroke, and obesity. Now, a team of scientists in China has found …

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